PUBLICATIONS
San Martin, R., Moffitt, A., Loveless, T., Brixius-Anderko, S.* (2022) Recruiting Women Faculty through Inclusive, Family-Friendly Practices. Trends in Biochemical Sciences, accepted (*Corresponding author)
Loomis C.L., Brixius-Anderko, S., Scott, E.E. (2022) Redox Partner Adrenodoxin Alters Cytochrome P450 11B1 Ligand Binding and Inhibition. Journal of Inorganic Biochemistry ICCP450 Special Issue, in press
Brixius-Anderko, S., Scott, E.E. (2021) Aldosterone synthase structure with Cushing Disease drug LCI699 highlights avenues for selective CYP11B drug design. Hypertension, 78(3):751-759, PMID: 34247511
Brixius-Anderko, S., Scott, E.E. (2021) Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin. Journal of Biological Chemistry, Jan-Jun 2021;296:100794. PMID: 34015331
Wróbel, T.M., Rogova, O., Anderson, K.L., Yadav, R., Brixius-Anderko, S., Scott, E.E., Olsen, L., Jørgensen, F.S., Björkling, F. (2020) Discovery of novel non-steroidal cytochrome P450 17A1 inhibitors as potential prostate cancer agents. International Journal of Molecular Sciences, 21:4868-4879, PMID: 32660148
Koenig, L., Szczesny, S., Brixius-Anderko, S., M., Hannemann, F., Bernhardt, R. (2020) Mixed-culture fermentation for enhanced C21 hydroxylation of glucocorticoids. Journal of Biotechnology, 314-315:14-24, PMID: 32246945
Koenig, L., Brixius-Anderko, S., Tavouli, D., Milhim, M., Hannemann, F., Bernhardt, R. (2019) Identification and circumvention of bottlenecks in CYP21A2-mediated premedrol production using recombinant Escherichia coli. Biotechnology and Bioengineering, 117(4):901-911, PMID: 31814109
Malikova, J., Zingg, T., Fingerhut, R., Sluka, S., Groessl, M., Brixius-Anderko, S., Bernhardt, R., McDougall, J., Pandey, A.V., Flück, C. (2019) HIV drug efavirenz inhibits 21-hydroxylase activity with possible clinical implications. Hormone Research in Pediatrics, 91(4):262-270, PMID: 31256164
Brixius-Anderko, S., Scott, E.E. (2018) Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design. Journal of Biological Chemistry, 294, 453-460, PMID: 30425102
Highlighted article in ASBMB Today (04/2019), Recommended reads JBC
Malikova, J.*, Brixius-Anderko, S.*, Udhane, S., Parween, S., Dick, B., Bernhardt, R., and Pandey, A. V. (2017) CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2. The Journal of Steroid Biochemistry and Molecular Biology, 174:192-200. PMID: 28893623 (*shared first authorship)
Brixius-Anderko, S., Hannemann, F., Ringle, M., Khatri, Y., and Bernhardt, R. (2016) An indole deficient Escherichia coli strain improves screening of cytochromes P450 for biotechnological applications. Biotechnology and Applied Biochemistry 64(3):315-326. PMID: 26913738.
Schiffer, L., Müller, A.-R., Hobler, A., Brixius-Anderko, S., Zapp, J., Hannemann, F., and Bernhardt, R. (2016) Biotransformation of the mineralocorticoid receptor antagonists spironolactone and canrenone by human CYP11B1 and CYP11B2: Characterization of the products and their influence on mineralocorticoid receptor transactivation, Journal of Steroid Biochemistry and Molecular Biology, 163:68-76. PMID: 27125452.
Schiffer, L., Brixius-Anderko, S., Hannemann, F., Zapp, J., Neunzig, J., Thevis, M., and Bernhardt, R. (2016) Metabolism of oral-turinabol by human steroid hormone- synthesizing cytochromes P450. Drug Metabolism and Disposition 44(2):227-37. PMID: 26658226.
Brixius-Anderko, S., Schiffer, L., Hannemann, F., Janocha, B., and Bernhardt, R. (2015) A CYP21A2 based whole-cell system in Escherichia coli for the biotechnological production of Premedrol. Microbial Cell Factories 14:135. PMCID: PMC4572648
Schiffer, L., Anderko, S., Hobler A., Hannemann F., Kagawa N., and Bernhardt, R. (2015) A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale. Microbial Cell Factories 14:25. PMCID: PMC4347555.
Schiffer, L., Anderko, S., Hannemann, F., Eiden-Plach, A., and Bernhardt, R. (2014) The CYP11B subfamily. The Journal of Steroid Biochemistry and Molecular Biology, 151:38-51. PMID: 25465475.
PATENTS
Lattemann, C., Stillger, T., Janocha, B., Rasser, H.-F., Rissom, S., Anderko, S., Bernhardt R., Hannemann, F. 21-Hydroxylation of Steroids, Patent application US10385376B2 (USA, granted), EP3212800A1 (European, pending), JP2017532057A (Japan, pending), CA2966067A1 (Canada, pending), WO2016066738A1 (WIPO, pending)
The Brixius Lab 